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  Figure 8.1 -In Figure 8.1, if the presynaptic neuron is cholinergic, what is the structure in Step 6? A) dopa decarboxylase B) catechol- O- methyltransferase C) monoamine oxidase D) choline acetyl transferase E) acetylcholinesterase Figure 8.1 -In Figure 8.1, if the presynaptic neuron is cholinergic, what is the structure in Step 6?


A) dopa decarboxylase
B) catechol- O- methyltransferase
C) monoamine oxidase
D) choline acetyl transferase
E) acetylcholinesterase

F) C) and E)
G) D) and E)

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must be actively taken up by cholinergic neurons in order to synthesize neurotransmitter.


A) Choline
B) Acetyl
C) DOPA
D) Acetylcholine
E) ATP

F) B) and D)
G) C) and E)

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For ionotropic receptors, their response the likelihood that two pulses from the same neuron will summate.


A) rapid : decreases
B) slow : increases
C) rapid : does not affect
D) rapid : increases
E) slow : decreases

F) All of the above
G) A) and D)

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The similarity in structure between glutamate and GABA are indicative of the similarity in their function.

A) True
B) False

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Biogenic amines are synthesized in what region of a neuron?


A) extracellular space
B) rough endoplasmic reticulum
C) axon hillock
D) cytosol of the axon terminal
E) cytosol of the cell body

F) B) and D)
G) C) and E)

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The action of any chemical messenger ultimately depends not on the nature of the messenger, but rather on the


A) nerve cell stimulated.
B) half- life of the messenger.
C) affinity of the receptor.
D) signal transduction mechanism activated.
E) organ system activated.

F) C) and E)
G) B) and C)

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Which of the following neurotransmitters is an amino acid neurotransmitter released at inhibitory synapses?


A) aspartate
B) norepinephrine
C) substance P
D) acetylcholine
E) glycine

F) A) and B)
G) A) and C)

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Postsynaptic potentials generated by neurotransmitter binding to receptors on the postsynaptic membrane can be excitatory or inhibitory. Describe excitatory postsynaptic potentials and their temporal characteristics.

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Excitatory postsynaptic potentials (EPSP...

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What type of ion channels is necessary for the function of the axon and the axon terminal?


A) ligand- gated
B) chemically- gated
C) receptor- gated
D) mechanically- gated
E) voltage- gated

F) A) and E)
G) B) and E)

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Once initiated, excitatory postsynaptic potentials last for hours, especially if a fast receptor is activated.

A) True
B) False

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At metabotropic receptors, a(n)


A) neurotransmitter binding to a receptor stimulates a G- protein, which then activates a second messenger through one or more enzymatic actions.
B) neurotransmitter binding to a receptor opens channels that are a separate protein from the receptor.
C) neurotransmitter binding to a receptor opens or closes channels that are part of the same protein as the receptor.
D) ion binding to a receptor opens channels in the plasma membrane.
E) neurotransmitter binding to a receptor opens or closes channels that are a separate protein from the receptor.

F) B) and C)
G) A) and E)

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What chemical targets CB1 receptors?


A) carbonic acid
B) carbon dioxide
C) glutamate
D) enkephalin
E) tetrahydrocannabinol

F) C) and D)
G) C) and E)

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Presynaptic modulation of neurotransmitter release involves modifying at the axon terminal.


A) potassium channels
B) membrane potential
C) sodium channels
D) calcium influx
E) the vesicles selected for release

F) A) and B)
G) A) and C)

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Neurotransmitter release occurs by what mechanism?


A) endocytosis
B) secondary active transport
C) diffusion
D) exocytosis
E) primary active transport

F) A) and B)
G) B) and E)

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Once released, acetylcholine is degraded by extracellular enzymes into what product(s) ?


A) acetyl CoA + choline
B) acetate only
C) choline only
D) methylcholine + acetate
E) acetate + choline

F) A) and B)
G) A) and C)

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Presynaptic modulation occurs at what type of synapse?


A) axodendritic
B) axoaxonic
C) axosomatic
D) dendrodendritic
E) dendrosomatic

F) B) and E)
G) A) and B)

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Information travels through the nervous system along the axons as action potentials. These action potentials must be transmitted across the synaptic cleft. Describe the process whereby an action potential that has entered the axon terminal is able to induce a change in membrane potential in the postsynaptic membrane, following neurotransmitter binding to a metabotropic receptor.

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indirectly through the activation of a s...

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Adenosine is degraded by nucleotidases.

A) True
B) False

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Which of the following couplings between neurotransmitter and neurotransmitter class is INCORRECT?


A) histamine : biogenic amine
B) adenosine : amino acid
C) nitric oxide : gas
D) norepinephrine : catecholamine
E) enkephalin : neuropeptide

F) None of the above
G) B) and E)

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Convergence in neurophysiology refers to which of the following?


A) the communication of several neurons to one postsynaptic cell
B) the summation of graded potentials to determine whether or not an action potential will be generated
C) the presence of EPSPs and IPSPs on a neuron at the same time
D) the level of depolarization required to generate an action potential
E) the arrival of an action potential at the axon terminal

F) C) and E)
G) A) and B)

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