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If 100 cups of strong coffee contain a lethal dose of caffeine, why don't coffee drinkers eventually die from caffeine overdose?


A) Coffee drinkers who drink more than 100 cups of coffee a week will eventually die from the bioaccumulation.
B) Because of its molecular form, all of the caffeine is not actually absorbed into the body.
C) Once the coffee cools, the caffeine is not as strong as it was when the coffee was fresh.
D) Coffee drinkers who drink more than 100 cups of coffee a month will eventually die from the bioaccumulation.
E) Our bodies metabolize the caffeine before lethal concentrations are reached.

F) A) and B)
G) B) and C)

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Most people do their own personal risk assessments based upon


A) Scientific data
B) Whimsical preference devoid of logic
C) Logical reasoning about relative risks
D) Personal biases and preferences as well as logic
E) Statistical probabilities

F) A) and C)
G) A) and B)

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Historically, the greatest threats to human health came from


A) Carcinogenic or toxic chemicals
B) Psychological stress factors due to crowding
C) Pathogenic organisms
D) Teratogenic chemicals
E) Injuries (intentional and unintentional)

F) A) and B)
G) A) and C)

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Substances that interrupt normal hormone action can impact human health in many ways beyond sexual function.

A) True
B) False

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Individuals represented by the left end of the dose/response curve (responding to doses between 0 and 10 ppm) are ______________ for that population.


A) Very sensitive
B) Very insensitive
C) About average in sensitivity
D) Relatively insensitive
E) Relatively sensitive

F) C) and E)
G) B) and E)

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Among the most important characteristics of chemicals in determining their environmental risks is/are


A) Solubility
B) Reactivity
C) Persistence
D) Toxicity
E) All of these

F) C) and E)
G) A) and D)

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Highly persistent toxic chemicals


A) Retain their toxicity as they cycle through the food chain and environment
B) Lose their toxicity once released in the environment
C) Accumulate within one organism but break down at higher trophic levels
D) Are highly unusual among artificial chemicals
E) Are usually not that toxic in their life span

F) A) and D)
G) A) and B)

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Tumors can grow because of exposure to


A) Neurotoxins
B) Mutagens
C) Antigens
D) Parasitic organisms
E) Allergens

F) A) and E)
G) B) and C)

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An LD50 is a dose of a toxic chemical that


A) Is an acceptable level of risk for most individuals
B) All individuals react to
C) Kills individuals 50 years old and obove
D) Is 50 times less than the minimal dose
E) Kills half of the population

F) None of the above
G) A) and B)

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In humans and other mammals, ingested poisons are primarily detoxified by the


A) kidneys.
B) liver.
C) pancreas.
D) stomach.

E) A) and B)
F) None of the above

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Which of the following factors would explain the seemingly irrational behavior of a father who smokes (high-risk factor for baby) but throws away his baby's teething rings that may contain phthalates (seemingly low-risk factor for baby) ?


A) People tend to downplay risks that are associated with activities they are committed to or enjoy.
B) Most people do not understand the concepts of probability.
C) News media can give a biased view of hazards.
D) People tend to have an irrational fear of certain technologies that are not as well understood.
E) All of these factors can lead to the relatively irrational behavior demonstrated by the father.

F) A) and B)
G) A) and C)

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The biomagnification of DDT demonstrates that


A) Higher trophic level organisms can concentrate toxins in a type of "inverse biological pyramid."
B) Birds should not depend on fish for food
C) DDT is easily metabolized and excreted by most organisms
D) DDT is an extremely water-soluble material
E) Water-soluble toxins are widespread

F) None of the above
G) B) and D)

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Hazardous substances ______________ while toxins are ______________.


A) React with specific cell components to kill cells; poisonous substances
B) Are dangerous substances; poisonous substances
C) Are usually of concern at all concentrations; dangerous substances
D) Are poisonous substances; also poisonous substances
E) None of the above is correct

F) All of the above
G) D) and E)

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Bioaccumulation is important because it allows cells to


A) Accumulate essential nutrients and minerals
B) Rid themselves of waste material
C) Protect themselves against toxins
D) Reproduce more quickly
E) Have a ready source of energy if it is needed

F) C) and E)
G) A) and D)

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Detection of toxic chemicals depends upon


A) How many chemicals are present
B) How many individuals respond to them at a certain dosage
C) The sensitivity of measuring techniques and how many chemicals are present
D) Whether or not individuals or groups of individuals are sensitive to them
E) Whether or not groups of individuals are sensitive to them

F) A) and B)
G) A) and C)

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Historically, which of the following considerations in setting standards for toxic exposure has been emphasized the least?


A) Including information about how toxins affect natural ecological systems
B) Different members of the population have different sensitivities to toxins
C) Including information about both chronic and acute exposures to a toxin
D) Individuals in the human population have been exposed to many different kinds of toxins that may have additive or synergistic effects
E) All of these considerations have been used and are important in setting policy

F) B) and E)
G) C) and D)

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Between 1990 and 2010, what showed the biggest rank increase for the "Leading Causes of Global Disease Burden?"


A) HIV/AIDS
B) Malaria
C) Stroke
D) Diabetes

E) A) and D)
F) A) and B)

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Two problems encountered in human health risk assessment are _______________________ and ___________________.


A) Use of chemical mixtures; lack of knowledge about synergistic effects
B) Lack of funding for federal mandates; lack of public support
C) Extrapolation of data to low doses; extrapolation of data from nonhuman species to humans
D) Lack of planning; the involvement of politics
E) There are no inherent problems in human health risk assessment

F) A) and E)
G) C) and D)

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An interaction between substances which exacerbates their effects is known as


A) complex amalgamation.
B) synergism.
C) sympatric interconnectivity.
D) None of these choices are correct

E) A) and B)
F) A) and C)

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_______________, rather than ______________, are becoming the leading causes of disability and premature death worldwide.


A) Chronic conditions such as cardiovascular disease; infectious diseases such as malaria
B) Infectious diseases such as malaria; chronic conditions such as cardiovascular disease
C) Traffic deaths; infectious diseases such as malaria
D) Chronic conditions such as cardiovascular disease; traffic deaths
E) Infectious diseases such as malaria; traffic deaths

F) D) and E)
G) B) and D)

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